Startup Guide: Wilmington, NC: Diving deep on The Port City’s startup scene and resources for entrepreneurs.

Wilmington, North Carolina is often best known for its beaches, historic port, and film-industry roots — but over the past decade, it has quietly become one of the Southeast’s most compelling emerging startup hubs. What was once perceived mainly as a coastal lifestyle city has evolved into a dynamic innovation community shaped by fintech wins, a strong university talent pipeline, coordinated ecosystem building, and a growing investor base – and the city was the fastest growing in the United States in 2024, according to moving data from United Van Lines.

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Wilmington’s growth story begins with a series of structural shifts. The extension of I-40 into Wilmington in 1990 opened the door to stronger connectivity across the state. Life sciences firms like PPD and Trans 1 Pharma grew substantial local teams, while Screen Gems Studios produced multiple major films, bringing new creative and economic energy into the region. But a key underlying catalyst came from Live Oak Bank, whose technology-forward approach to small business lending helped create a cluster that still shapes Wilmington today. A back-office software tool built inside Live Oak eventually spun out to become nCino, one of the most successful fintech companies ever founded in the Southeast. nCino scaled rapidly, raised more than $200M, and ultimately went public in 2020 — placing Wilmington on the national fintech map and generating a strong pipeline of experienced operators, Salesforce talent, and future founders. Live Oak continued reinforcing this momentum by co-founding Apiture, launching one of the largest tech VC funds in the South in Canapi Ventures (now managing more than $750M), and building a culture of tech innovation that became central to Wilmington’s economic identity.

This momentum has helped contribute to the incredible surge Wilmington is experiencing. Live Oak Bank, nCino, and Apiture have collectively hired more than 1,000 UNC Wilmington graduates, establishing a reliable technical and operational talent base. Healthtech, biotech, and deeptech startups have also gained traction, supported by a collaborative set of ecosystem builders and a quality of life that attracts both young founders and experienced executives; OpiAID, Boreas Monitoring Solutions, NUREAM, Artemis Immersive, CareHome Health Solutions and Predicate AI are just a subset of the exciting names succeeding in Wilmington, and community software provider Vantaca just achieved unicorn status with a $1.25B valuation in October 2025.

UNCW has played a foundational role in this evolution. Under former chancellor Gary Miller, the university launched the Center for Innovation & Entrepreneurship (CIE) — one of the region’s earliest dedicated entrepreneurship hubs, which helped lay the groundwork for the now-powerful entrepreneur ecosystem in Wilmington. CIE now serves as a connector between students, founders, mentors, and investors, helping build an ecosystem supported by more than a dozen organizations and partners in the Wilmington Small Business Coalition. Groups like Network for Entrepreneurs in Wilmington (NEW), Genesis Block, WALE Angel Network, VentureSouth and Wilmington Investor Network (WIN) provide resources, programming, and capital that many founders rely on at the earliest stages.

Wilmington’s greatest differentiator, however, remains its quality of place. Entrepreneurs cite the city’s coastal lifestyle, low congestion, and strong sense of community as reasons to build their companies here rather than in larger, more competitive metros. Wilmington also benefits from close proximity to Raleigh-Durham — enabling founders to “borrow” infrastructure, investors, and research support from the Triangle while offering statewide organizations an appealing beach-adjacent destination for programming and retreats.

Today, Wilmington’s economy blends fintech, life sciences, healthtech, and software in a way that is unusual for a metro of its size. Talent from Live Oak, nCino, and Apiture has seeded new ventures; biotech and pharma logistics firms are expanding; and UNCW continues growing its innovation footprint. Together, these forces position Wilmington as a rising coastal innovation hub in the Southeast.

Images of Wilmington’s waterfront scene.

Resources for Startups

Investors

Incubators & Accelerators

Coworking Spaces

  • UNCW CIE – University-anchored coworking hub with founder programs, mentorship, and a collaborative innovation community.
  • Common Desk – Downtown – Modern, amenity-rich workspace in the heart of downtown
  • Blue Mind Coworking – Flexible, quiet workspace near the county center, popular with professionals and founders.
  • Channel by Live Oak Bank — Vibrant coworking community supporting minority entrepreneurs with programming and resources.
  • Elevate Coworking – Women-focused workspace fostering collaboration, mentorship, and supportive entrepreneurship networks.
  • Coworx at Cargo District — Creative mixed-use coworking space within Wilmington’s popular Cargo District community.
  • 717 MKT Office Collaborative – Boutique workspace offering private offices, team studios, rooftop views, and premium amenities.

Communities & Event Organizers

Notable Annual Events

3rd Annual Wilmington INVESTOR BUZZ IN event.

Startups to Watch

Approve – Tech-enabled equipment financing platform streamlining underwriting and procurement for SMBs; founded by the team behind Kwipped and supported by regional early-stage investors.

Artemis Immersive – Healthtech startup creating 3D medical animations for clinical training and education, founded by UNCW graduates and gaining early adoption among health organizations.

Boreas Monitoring Solutions – Cryotank monitoring system helping fertility clinics prevent failures through real-time temperature, alarm, and data tracking; backed by early institutional and angel investors.

Brilliant Sole – IoT-enabled smart footwear improving senior fall prevention and enhancing motion capture for gaming; operating across digital health and immersive tech markets.

CareHome Health Solutions– Medication management and care-coordination platform helping seniors and caregivers manage prescriptions safely and effectively, with early traction among home-care organizations.

DuraVax – UNCW biotech spinoff developing improved delivery methods for vaccines and essential medicines; progressing through early commercialization and grant-supported research.

Essential Personnel – Software for First Responder types of organizations for federally required wellness concerns. Founders are military veterans.

Isosceles Pharmaceuticals – A preclinical stage pharmaceutical company, currently developing intravenous formulations of synthetic Cannabidiol, one of the many active chemicals in cannabis, as a non-addictive alternative to opium-derived painkillers

LabLogs – Workflow automation software designed for clinical and research laboratories, improving documentation, compliance, and QA processes for smaller labs.

Lumos Data – Customizable fintech data infrastructure helping lenders better evaluate small business credit risk; scaling through community banks and credit unions.

NxtGen Care – AI and IOT for nursing homes to improve care and reduce caregiver burden.

NUREAM – Sleep-tech company using connected textiles to gather biometric signals and improve sleep quality; building clinical partnerships to validate its technology.

Ohanafy – Beverage-industry CRM and operations platform built by former nCino employees; venture-backed and experiencing rapid national customer growth among breweries and distilleries.

OPIAID – AI-driven addiction recovery platform providing clinics with insight into patient treatment pathways and personalized care recommendations.

Portrett Pharmaceuticals – Biotech specializing in small molecule testing, offering services like stability testing, method validation, compendial testing, and impurity analysis.

Predicate AI – Health analytics company improving early detection of hospital-acquired conditions; secured a major partnership with Mayo Clinic to scale sepsis prediction tools.

Raleon – Customer retention marketing startup founded by a former nCino executive; acquired by Intuit following strong traction in the DTC ecosystem.

Skillmaker.AI – AI-driven workforce training platform recently partnering with NAPA Auto Parts to scale skill development across automotive service centers.

SportBase – Sports club management system built by former directors to streamline youth sports scheduling, payments, and operations.

SynPly – Fintech workflow platform improving loan servicing, documentation, and partnership management for lenders and credit providers.

Vantaca – AI-enabled software for HOA organizations; raised $300 million and earned unicorn status in October 2025.

Local Favorites (Eat, Drink, Explore)

Ocean Grill & Tiki Bar – A quintessential Carolina Beach hangout perched above the dunes, offering fresh seafood, ocean breezes, and a laid-back atmosphere perfect for unwinding after a long day of meetings or beach time.

Beer Barrio – A downtown favorite blending Cali-Mex flavors with a coastal twist. Known for its award-winning burritos, house-made salsas, and friendly service, it’s a go-to for casual lunches and post-work meetups.

End of Days Distillery – One of Wilmington’s standout craft distilleries, serving small-batch spirits in a relaxed indoor-outdoor space. Features rotating food trucks and frequent community events, making it a great spot to gather.

Covey – Covey is a neighborhood restaurant in midtown Wilmington with a focus on exceptional service, fresh and local ingredients, and with a unique atmosphere.

K38 Baja Grill – A long-time regional staple combining Baja-style dishes with local seafood. With several locations across the Wilmington area, it’s dependable for team lunches or casual dinners with visiting founders.

Wilmington Brewing Company – Beloved for its “Tropical Lightning” IPA and easygoing taproom, this family-run brewery draws both locals and visitors. A great place to taste what the city’s craft beer scene is all about.

Seabird – An elevated but welcoming downtown restaurant from one of Wilmington’s most celebrated chefs. Featuring seasonal Southern coastal cuisine, it’s a top pick for business dinners or special nights out.

Live Oak Pavilion – Wilmington’s signature riverfront music venue, hosting national touring acts with scenic views of the Cape Fear River. Ideal for catching a show after a full day of meetings or exploring downtown.

Greenfield Lake Amphitheater – A picturesque sunset venue nestled beside Greenfield Lake, offering a more intimate concert experience with artists across rock, indie, and jazz.

North Carolina Azalea Festival – A beloved Wilmington tradition every spring, filled with concerts, garden tours, local showcases, and the iconic Garden Party — a uniquely Southern blend of style, community, and celebration.

What’s Next for Wilmington

Wilmington is entering a new phase as a maturing coastal innovation hub. Fintech remains a competitive advantage, with a growing number of nCino and Apiture alumni launching new ventures. Healthtech, deeptech, and biotech activities are picking up with additional SBIR and grant funding resources; the concept of water- and ocean-focused bluetech is expanding around UNCW’s research footprint with the annual Ocean Innovation Conference. Angel networks are becoming more active by syndicating deals with other regional funds as more executives and retirees relocate to the coast. And ties with Raleigh-Durham are strengthening, enabling the city to plug into a broader statewide innovation ecosystem without losing its coastal identity.

With strong support organizations, a proven talent engine, and one of the most distinctive qualities of place in the Southeast, Wilmington is well positioned to keep rising as a destination for founders who want to build ambitious companies in a collaborative, coastal environment.

Wilmington’s signature I Believe in Wilmington mural.

This guide was written by Jim Roberts, a longtime participant in and supporter of the entrepreneurship ecosystem in Wilmington and broader North Carolina. Jim is the founder of the WALE Angel Network and the Network for Entrepreneurs in Wilmington (NEW). Jim was previously the Founding Executive Director of the UNCW Center for Innovation and Entrepreneurship in 2013; he raised funds to start the Bunker Labs Wilmington Chapter, and started the first Tech Entrepreneur Support Orgs in Charlotte, Asheville and Wilmington. Jim was previously a NC Department of Commerce employee in Raleigh, and worked for the NC Biotech Center with a spinout org called COI for NanoBiotechnology in Durham.

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11/29/2025
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